Quinolines block every step of malaria heme crystal growth.

an ice core on the Antarctic Plateau as part of a long-term European ice core drilling collaboration. Michael Bock et al. found that seasonal floods and tropical wetlands likely controlled atmospheric methane concentrations during the current and two older interglacial periods as well as their preceding glacial maxima, and that geologic methane emissions may have a constant but minor role in atmospheric methane fluctuations. According to the authors, increased fire activity may have influenced methane stable isotope levels throughout the last 25,000 years. See the article by Michael Bock et al. on pages E5778–E5786. Image courtesy of Thibaut Vergoz (National Center for Scientific Research, Paris). From the Cover